Pan, Wen-Harn潘文涵

Joint Appointment Research Fellow

Research Interests

Cardiovascular Epidemiology, Nutrition Survey and Intervention, Food Omics Signature, PM2.5 for fried oil fume

Representative Publications

Biradar MI, Chiang KM, Yang HC, Huang YT, Pan WH* (2020) The causal role of elevated uric acid and waist circumference on the risk of metabolic syndrome components. Int J Obes (Lond).  44(4):865-874.

Wang LJ, Yu YH, Fu ML, Yeh WT, Hsu JL, Yang YH, Yang HT, Huang SY, Wei IL, Chen WJ, Chiang BL, Pan WH* (2019) Dietary Profiles, Nutritional Biochemistry Status, and Attention-Deficit/Hyperactivity Disorder: Path Analysis for a Case-Control Study. J Clin Med. 8(5),709.

Chiang KM, Tsay YC, Vincent Ng TC, Yang HC, Huang YT, Chen CH, Pan WH* (2019) Is Hyperuricemia, an Early-Onset Metabolic Disorder, Causally Associated with Cardiovascular Disease Events in Han Chinese? J Clin Med. 12;8(8)

Hsieh TJ, Su SC, Chen CW, Kang YW, Hu MH, Hsu LL, Wu SY, Chen L, Chang HY, Chuang SY, Pan WH*, Hsu CC* (2019)  Individualized home-based exercise and nutrition interventions improve frailty in older adults: a randomized controlled trial. Int J Behav Nutr Phys Act. 16(1):119.

Chuang SY, Lo YL, Wu SY, Wang PN, Pan WH* (2019) Dietary Patterns and Foods Associated With Cognitive Function in Taiwanese Older Adults: The Cross-sectional and Longitudinal Studies. J Am Med Dir Assoc. 20(5):544-550.

Wu SY, Hsu LL, Hsu CC, Hsieh TJ, Su SC, Peng YW, Guo TM, Kang YW, Pan WH* (2018) Dietary education with customised dishware and food supplements can reduce frailty and improve mental well-being in elderly people: A single-blind randomized controlled study. Asia Pac J Clin Nutr. 27(5):1018-1030.

Pan WH*, Lai YH, Yeh WT, Chen JR, Jeng JS, Bai CH, Lin RT, Lee TH, Chang KC, Lin HJ, Hsiao CF, Chern CM, Lien LM, Liu CH, Chen WH, Chang A (2017) Intake of potassium- and magnesium-enriched salt improves functional outcome after stroke: a randomized, multicenter, double-blind controlled trial. Am J Clin Nutr. 106(5):1267-1273.

Lo YL, Hsieh YT, Hsu LL, Chuang SY, Chang HY, Hsu CC, Chen CY, Pan WH*  (2017) Dietary Pattern Associated with Frailty: Results from Nutrition and Health Survey in Taiwan. J Am Geriatr Soc. 65(9):2009-2015.

Chuang SY, Cheng HM, Bai CH, Yeh WT, Chen JR, Pan WH* (2016) Blood Pressure, Carotid Flow Pulsatility, and the Risk of Stroke: A Community-Based Study. Stroke. 47(9):2262-8.

Lynn KS, Cheng ML, Chen YR, Hsu C, Chen A, Lih TM, Chang HY, Huang CJ, Shiao MS, Pan WH*, Sung TY*, Hsu WL* (2015) Metabolite identification for mass spectrometry-based metabolomics using multiple types of correlated ion information. Anal Chem. 87(4):2143-51.


The Mediterranean diet reduces the genetic risk of chromosome 9p21 for myocardial infarction in an Asian population community cohort The interaction of genetic susceptibility and dietary habits in cardiovascular disease (CVD) remains undetermined. The purpose of this study was to investigate whether a Mediterranean dietary style modified the genetic risk of developing CVD in a Chinese cohort. A total of 2098 subjects with dietary information from a Chinese community cohort (CVDFACTS) were enrolled. Candidate genes, including SNP markers rs1333049 (CDKN2B, 9p21.3), rs17465637 (MIA3, 1q41) and rs501120 (CXCL12, 10q11.21), were genotyped to analyze the association with future CVD. The impact of dietary pattern was also analyzed according to adherence to the diet using the Mediterranean Diet Score (MDS). After an average follow-up of 7.8 years, only the C risk allele of rs1333049 at chromosome 9p21.3 was associated with a higher risk of MI with either an additive [HR = 1.78, 95% CI:1.23–2.5] or a recessive model [HR = 2.40, 95% CI: 1.42–4.04], and the CC genotype had a higher risk of developing MI (p = 0.009, log-rank test). There was no significant difference in the association of the lipid profile with future CV outcomes among the MDS tertiles. However, the high MI risk of the CC genotype in individuals consuming a less healthy diet (MDS1) (HR: 6.39, 95% CI: 1.74–23.43) significantly decreased to 2.38 (95% CI: 0.57–10.04) in individuals consuming a healthier diet (MDS3), indicating that a healthier dietary pattern (higher MDS) modified the risk of developing MI in carriers of variants in CDKN2B. In conclusion, genetic variants of CDKN2B at 9p21 were significantly associated with future MI risk in a Chinese cohort, and the genetic risk of MI could be modified by a healthier diet.

Individualized home-based exercise and nutrition interventions improve frailty in older adults: a randomized controlled trial Frail older adults are predisposed to multiple comorbidities and adverse events. Recent interventional studies have shown that frailty can be improved and managed. In this study, effective individualized home-based exercise and nutrition interventions were developed for reducing frailty in older adults.The designated home-based exercise and nutrition interventions can help pre-frail or frail older adults to improve their frailty score and physical performance.

The causal role of elevated uric acid and waist circumference on the risk of metabolic syndrome components Hyperuricemia has been found to cluster with multiple components of metabolic syndrome (MetS). It is unclear whether hyperuricemia is a downstream result of MetS or may play an upstream role in MetS development. Using the Mendelian randomization (MR) method, we examined the causal relationship between elevated uric acid and the various components of MetS with waist circumference as a positive control.Our MR investigation shows that uric acid increment may augment the risk of MetS through increasing blood pressure and triglyceride levels and lowering HDL-C value but not through accumulating fat or hyperglycemia. High waist circumference may be a causal agent for all the components of MetS including hyperuricemia.

  • Affiliation:
    Distinguished Research Fellow,
    Institute of Biomedical Sciences,
    Academia Sinica
  • Ph.D. Nutritional Epidemiology,
    Division of Nutritional Sciences,
    Cornell University, USA(1983)
  • MS, Nutritional Biochemistry,
    Division of Nutritional Sciences,
    Cornell University, USA(1979)
  • BS,
    Agricultural Chemistry,
    National Taiwan University, Taiwan (1976)